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Principal Scientist, Structural Biology and Biophysics

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Vertex Pharmaceuticals Inc (US)

US

9 days ago
full-time
No degree mentioned

Job Description

Description

Job Description Position Summary: The Structural Biology and Biophysics group at Vertex Pharmaceuticals is responsible for generating reagents as well as biophysical and structural information that is critical for the advancement of research programs to create transformative medicines for patients with serious diseases. The group is seeking a highly motivated and collaborative Principal Research Scientist with significant experience utilizing biophysical methods and CryoEM for structure-based drug design to help guide these efforts. The ideal candidate for this lab-based role will possess excellent technical skills in sample handling for biophysical studies of small molecule ligand binding and utilization of CryoEM, a proven track record in drug discovery, strong communication skills, and the ability to collaborate with members of an interdisciplinary project team. Key Duties and Responsibilities: Work within drug discovery project teams to design and execute biophysical experiments that answer key questions and aid in molecular design Develop and execute ligand binding studies using Surface Plasmon Resonance (SPR), Thermal Shift Analysis (TSA), Isothermal Titration Calorimetry (ITC) Design and generation of reagents for biophysical studies Determine structures using CryoEM and application for structure-based design Sample preparation, execution of experiments, and organized reporting of results Keep up to date with the scientific literature in the field and beyond Actively participate in group and cross-disciplinary project team meetings Present results to project teams in a clear and understandable way Knowledge and Skills: Significant experience working with integrated drug discovery teams utilizing structure-based drug design. Deep understanding of biophysical and structural methods Ability to develop and execute biophysical assays to measure ligand binding Experience with CryoEM data collection, structure determination, and analysis Experience with hit-to-lead activities Track record of productivity as evidenced by a strong publication record Self-motivation, organization, and ability to communicate effectively with project teams Education and Experience: Ph.D. (or equivalent degree) in biological science and 4-7 years of relevant post-doctoral employment experience, or Masters Degree (or equivalent degree) in biological science and 7+ years of relevant employment experience, or Bachelors Degree (or equivalent degree) in biological science and 10+ years of relevant employment experience Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.